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First Trust NYSE Arca Biotechnology ETF (FBT) and First Trust AlphaDEX U.S. Health Care Sector Index ETF (FHH) offer distinct profiles for Canadian ETF investors. A direct comparison shows that FBT focuses its top 3 sector exposures on Healthcare, while FHH leans towards Healthcare. When evaluating costs, FBT features a management fee (MER) of 0.15%, compared to 0.7% for FHH. Performance-wise, FBT has returned 35.66% year-to-date with +$4 M in net flows, whereas FHH is at 19.24% with -$2 M. Use the comparison tool below to benchmark these funds across top 10 holdings, yield, sector weights and historical returns.
NAV Performance and Flows
Key Data
Compare
FBT
FHH
| AuM | $7.75 M | $4.99 M |
| Management Fees | 0.15% | 0.70% |
| Exp. ratio | 0.71% | 0.76% |
| Tracking Difference | - | -1.12% |
Historical performance and flows
As of September 22, 2026
| 1M | 3M | YTD | 1Y | 3Y | ||
|---|---|---|---|---|---|---|
| Perf. | FBT | +3.37% | +18.27% | +35.66% | +54.10% | +95.86% |
FHH | -0.39% | +13.57% | +19.24% | +24.03% | +41.93% | |
| Flows | FBT | +$0 M | +$2 M | +$4 M | +$4 M | +$4 M |
FHH | +$0 M | +$0 M | -$2 M | -$4 M | -$8 M |
FBT vs FHH exposure
Countries
FBT
USA
82.19%
Other
17.81%
FHH
USA
93.07%
Sectors
FBT
Healthcare
99.86%
FHH
Healthcare
98.24%
As of September 22, 2026
Top 10 Holdings
FBT
Halozyme Therapeutics, Inc.
4.31%
Corcept Therapeutics, Inc.
4.08%
Repligen Corp.
3.87%
Regeneron Pharmaceuticals, Inc.
3.85%
BeOne Medicines Ltd.
3.83%
BioNTech SE
3.75%
Natera, Inc.
3.73%
Amgen, Inc.
3.70%
argenx SE
3.66%
NeoGenomics, Inc.
3.63%
FHH
Regeneron Pharmaceuticals, Inc.
2.85%
Natera, Inc.
2.57%
Universal Health Services, Inc.
2.50%
Boston Scientific Corp.
2.49%
Pfizer Inc.
2.48%
Solventum Corp.
2.47%
Zimmer Biomet Holdings, Inc.
2.47%
Guardant Health, Inc.
2.41%
Tenet Healthcare Corp.
2.34%
Globus Medical, Inc.
2.33%
Diversification
FBT
Total weight of top 10 holdings out of 30 total
38.41%
FHH
Total weight of top 10 holdings out of 72 total
24.91%
Characteristics
Compare
FBT
FHH
| Provider | First Trust | First Trust |
| Management | Passively managed | Passively managed |
| Benchmark | NYSE Arca Biotechnology Total Return Index - USD | StrataQuant Health Care CAD Total Return Index - CAD |
| Replication Method | Direct (Physical) | |
| Asset Class | Equity | Equity |
| Dividend Policy | Distributing | Distributing |
| Trailing 12m distribution yield | 0.00% | 0.50% |
| Meets ESG criteria | No | No |
| Inception Date | October 30, 2014 | October 30, 2014 |
Frequently asked questions about FBT and FHH
Which ETF has performed better year to date: FBT or FHH?
As of September 22, 2026, FBT has returned 35.66% year to date, while FHH has returned 19.24%. FBT is ahead on YTD performance.
Which ETF is larger by assets under management: FBT or FHH?
As of September 22, 2026, FBT manages $7.75 M in assets, while FHH manages $4.99 M. FBT is the larger fund by AUM.
How are FBT and FHH managed?
FBT is passively managed by First Trust. It tracks the NYSE Arca Biotechnology Total Return Index - USD benchmark. FHH is passively managed by First Trust. It tracks the StrataQuant Health Care CAD Total Return Index - CAD benchmark.
What sectors do FBT and FHH emphasize?
FBT is most exposed to Healthcare. FHH is most exposed to Healthcare.
Which ETF is attracting more investor flows: FBT or FHH?
Year to date, FBT has seen +$4.36 M in net flows, compared with -$2.10 M for FHH. FBT has attracted more net investor money so far.
How do the fees of FBT and FHH compare?
FBT has an expense ratio of 0.71%, while FHH has an expense ratio of 0.76%.
What are the top holdings of FBT and FHH?
FBT's largest holdings include Halozyme Therapeutics, Inc., Corcept Therapeutics, Inc., and Repligen Corp.. FHH's top holdings include Regeneron Pharmaceuticals, Inc., Natera, Inc., and Universal Health Services, Inc..
Which ETF is more diversified: FBT or FHH?
FBT holds 30 securities, while FHH holds 72. On holdings count, FHH is the more diversified portfolio.
Recent articles about FBT and FHH
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All content on the ETF Market Canada is for your general information use only, Cboe is not responsible for any use of content by you outside this scope. In particular, the content does not constitute any form of advice, recommendation, representation, endorsement or arrangement by Cboe and is not intended to be relied upon by users in making (or refraining from making) any specific investment or other decisions.




