VS
iShares Genomics Immunology and Healthcare Index ETF (XDNA) and iShares Core S&P/TSX Capped Composite Index ETF (XIC) offer distinct profiles for Canadian ETF investors. A direct comparison shows that XDNA focuses its top 3 sector exposures on Healthcare, while XIC leans towards Finance, Energy, and Non-Energy Materials. When evaluating costs, XDNA features a management fee (MER) of 0.39%, compared to 0.05% for XIC. Performance-wise, XDNA has returned 53.58% year-to-date with +$6 M in net flows, whereas XIC is at 16.76% with +$9 B. Use the comparison tool below to benchmark these funds across top 10 holdings, yield, sector weights and historical returns.
NAV Performance and Flows
Key Data
Compare
XDNA
XIC
| AuM | $15.66 M | $34,600.11 M |
| Management Fees | 0.39% | 0.05% |
| Exp. ratio | 0.44% | 0.06% |
| Tracking Difference | -1.01% | -0.09% |
Historical performance and flows
As of September 4, 2026
| 1M | 3M | YTD | 1Y | 3Y | ||
|---|---|---|---|---|---|---|
| Perf. | XDNA | +18.91% | +32.72% | +53.58% | +77.75% | +84.03% |
XIC | +2.14% | +4.22% | +16.76% | +29.09% | +93.94% | |
| Flows | XDNA | +$3 M | +$5 M | +$6 M | +$6 M | +$6 M |
XIC | +$1,611 M | +$3,093 M | +$8,627 M | +$9,722 M | +$14,703 M |
XDNA vs XIC exposure
Countries
XDNA
USA
60.39%
Germany
8.55%
France
7.33%
Other
23.74%
XIC
Canada
96.46%
Sectors
XDNA
Healthcare
99.82%
XIC
Finance
41.74%
Energy
17.17%
Non-Energy Materials
15.75%
Industrials
8.14%
Other
17.19%
As of September 4, 2026
Top 10 Holdings
XDNA
Bayer AG
4.77%
Twist Bioscience Corp.
4.73%
Revolution Medicines, Inc.
4.61%
Moderna, Inc.
4.37%
Incyte Corp.
4.30%
Takeda Pharmaceutical Co., Ltd.
4.19%
Regeneron Pharmaceuticals, Inc.
4.16%
Genmab A/S
4.12%
Vertex Pharmaceuticals, Inc.
3.86%
Merck & Co., Inc.
3.85%
XIC
Royal Bank of Canada
8.10%
The Toronto-Dominion Bank
5.52%
Shopify, Inc.
4.12%
Bank of Montreal
3.45%
Enbridge, Inc.
3.34%
Canadian Imperial Bank of Commerce
3.00%
The Bank of Nova Scotia
2.98%
Canadian Natural Resources Ltd.
2.72%
Brookfield Corp.
2.48%
Suncor Energy, Inc.
2.17%
Diversification
XDNA
Total weight of top 10 holdings out of 47 total
42.96%
XIC
Total weight of top 10 holdings out of 219 total
37.87%
Characteristics
Compare
XDNA
XIC
| Provider | iShares | iShares |
| Management | Passively managed | Passively managed |
| Benchmark | NYSE FactSet Global Genomics and Immuno Biopharma NR Index - CAD | S&P/TSX Capped Composite Total Return Index - CAD |
| Replication Method | Direct (Physical) | Direct (Physical) |
| Asset Class | Equity | Equity |
| Dividend Policy | Distributing | Distributing |
| Trailing 12m distribution yield | 0.21% | 1.93% |
| Meets ESG criteria | No | No |
| Inception Date | April 26, 2022 | February 16, 2001 |
Frequently asked questions about XDNA and XIC
Which ETF has performed better year to date: XDNA or XIC?
As of September 4, 2026, XDNA has returned 53.58% year to date, while XIC has returned 16.76%. XDNA is ahead on YTD performance.
Which ETF is larger by assets under management: XDNA or XIC?
As of September 4, 2026, XDNA manages $15.66 M in assets, while XIC manages $34.60 B. XIC is the larger fund by AUM.
How are XDNA and XIC managed?
XDNA is passively managed by iShares. It tracks the NYSE FactSet Global Genomics and Immuno Biopharma NR Index - CAD benchmark. XIC is passively managed by iShares. It tracks the S&P/TSX Capped Composite Total Return Index - CAD benchmark.
What sectors do XDNA and XIC emphasize?
XDNA is most exposed to Healthcare. XIC is most exposed to Finance, Energy, and Non-Energy Materials.
Which ETF is attracting more investor flows: XDNA or XIC?
Year to date, XDNA has seen +$6.43 M in net flows, compared with +$8,626.58 M for XIC. XIC has attracted more net investor money so far.
How do the fees of XDNA and XIC compare?
XDNA has an expense ratio of 0.44%, while XIC has an expense ratio of 0.06%.
What are the top holdings of XDNA and XIC?
XDNA's largest holdings include Bayer AG, Twist Bioscience Corp., and Revolution Medicines, Inc.. XIC's top holdings include Royal Bank of Canada, The Toronto-Dominion Bank, and Shopify, Inc..
Which ETF is more diversified: XDNA or XIC?
XDNA holds 47 securities, while XIC holds 219. On holdings count, XIC is the more diversified portfolio.
Recent articles about XDNA and XIC
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