VS
iShares Genomics Immunology and Healthcare Index ETF (XDNA) and BMO Global Health Care Fund Active ETF Series (ZGHC) offer distinct profiles for Canadian ETF investors. A direct comparison shows that XDNA focuses its top 3 sector exposures on Healthcare, while ZGHC leans towards Healthcare, Consumer Non-Cyclicals, and Consumer Cyclicals. When evaluating costs, XDNA features a management fee (MER) of 0.39%, compared to 1.02% for ZGHC. Performance-wise, XDNA has returned 53.58% year-to-date with +$6 M in net flows, whereas ZGHC is at 7.99% with +$14 M. Use the comparison tool below to benchmark these funds across top 10 holdings, yield, sector weights and historical returns.
NAV Performance and Flows
Key Data
Compare
XDNA
ZGHC
| AuM | $15.66 M | $17.17 M |
| Management Fees | 0.39% | 1.02% |
| Exp. ratio | 0.44% | 0.82% |
| Tracking Difference | -1.01% | - |
Historical performance and flows
As of September 4, 2026
| 1M | 3M | YTD | 1Y | 3Y | ||
|---|---|---|---|---|---|---|
| Perf. | XDNA | +18.91% | +32.72% | +53.58% | +77.75% | +84.03% |
ZGHC | +3.34% | +9.67% | +7.99% | +16.31% | +28.46% | |
| Flows | XDNA | +$3 M | +$5 M | +$6 M | +$6 M | +$6 M |
ZGHC | +$0 M | +$7 M | +$14 M | -$108 M | +$16 M |
XDNA vs ZGHC exposure
Countries
XDNA
USA
60.39%
Germany
8.55%
France
7.33%
Other
23.74%
ZGHC
USA
80.14%
Switzerland
9.03%
Other
10.82%
Sectors
XDNA
Healthcare
99.82%
ZGHC
Healthcare
97.92%
As of September 4, 2026
Top 10 Holdings
XDNA
Bayer AG
4.77%
Twist Bioscience Corp.
4.73%
Revolution Medicines, Inc.
4.61%
Moderna, Inc.
4.37%
Incyte Corp.
4.30%
Takeda Pharmaceutical Co., Ltd.
4.19%
Regeneron Pharmaceuticals, Inc.
4.16%
Genmab A/S
4.12%
Vertex Pharmaceuticals, Inc.
3.86%
Merck & Co., Inc.
3.85%
ZGHC
Eli Lilly & Co.
9.90%
UnitedHealth Group, Inc.
7.55%
Johnson & Johnson
7.08%
Merck & Co., Inc.
6.72%
AbbVie, Inc.
5.73%
argenx SE
4.44%
AstraZeneca PLC
4.23%
Abbott Laboratories
3.96%
Novartis AG
3.75%
Thermo Fisher Scientific, Inc.
3.61%
Diversification
XDNA
Total weight of top 10 holdings out of 47 total
42.96%
ZGHC
Total weight of top 10 holdings out of 119 total
56.97%
Characteristics
Compare
XDNA
ZGHC
| Provider | iShares | BMO |
| Management | Passively managed | Actively managed |
| Benchmark | NYSE FactSet Global Genomics and Immuno Biopharma NR Index - CAD | - |
| Replication Method | Direct (Physical) | |
| Asset Class | Equity | Equity |
| Dividend Policy | Distributing | Distributing |
| Trailing 12m distribution yield | 0.21% | 0.00% |
| Meets ESG criteria | No | No |
| Inception Date | April 26, 2022 | June 26, 2023 |
Frequently asked questions about XDNA and ZGHC
Which ETF has performed better year to date: XDNA or ZGHC?
As of September 4, 2026, XDNA has returned 53.58% year to date, while ZGHC has returned 7.99%. XDNA is ahead on YTD performance.
Which ETF is larger by assets under management: XDNA or ZGHC?
As of September 4, 2026, XDNA manages $15.66 M in assets, while ZGHC manages $17.17 M. ZGHC is the larger fund by AUM.
How are XDNA and ZGHC managed?
XDNA is passively managed by iShares. It tracks the NYSE FactSet Global Genomics and Immuno Biopharma NR Index - CAD benchmark. ZGHC is actively managed by BMO. It does not track an index.
What sectors do XDNA and ZGHC emphasize?
XDNA is most exposed to Healthcare. ZGHC is most exposed to Healthcare, Consumer Non-Cyclicals, and Consumer Cyclicals.
Which ETF is attracting more investor flows: XDNA or ZGHC?
Year to date, XDNA has seen +$6.43 M in net flows, compared with +$13.52 M for ZGHC. ZGHC has attracted more net investor money so far.
How do the fees of XDNA and ZGHC compare?
XDNA has an expense ratio of 0.44%, while ZGHC has an expense ratio of 0.82%.
What are the top holdings of XDNA and ZGHC?
XDNA's largest holdings include Bayer AG, Twist Bioscience Corp., and Revolution Medicines, Inc.. ZGHC's top holdings include Eli Lilly & Co., UnitedHealth Group, Inc., and Johnson & Johnson.
Which ETF is more diversified: XDNA or ZGHC?
XDNA holds 47 securities, while ZGHC holds 117. On holdings count, ZGHC is the more diversified portfolio.
Recent articles about XDNA and ZGHC
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All content on the ETF Market Canada is for your general information use only, Cboe is not responsible for any use of content by you outside this scope. In particular, the content does not constitute any form of advice, recommendation, representation, endorsement or arrangement by Cboe and is not intended to be relied upon by users in making (or refraining from making) any specific investment or other decisions.