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iShares Genomics Immunology and Healthcare Index ETF (XDNA) and TD Global Healthcare Leaders Index ETF (TDOC.U) offer distinct profiles for Canadian ETF investors. A direct comparison shows that XDNA focuses its top 3 sector exposures on Healthcare, while TDOC.U leans towards Healthcare. When evaluating costs, XDNA features a management fee (MER) of 0.39%, compared to 0.35% for TDOC.U. Performance-wise, XDNA has returned 60.72% year-to-date with +$9 M in net flows, whereas TDOC.U is at 9.97% with -$0 M. Use the comparison tool below to benchmark these funds across top 10 holdings, yield, sector weights and historical returns.
NAV Performance and Flows
Key Data
Compare
XDNA
TDOC.U
| AuM | $19.37 M | $3.32 M |
| Management Fees | 0.39% | 0.35% |
| Exp. ratio | 0.44% | 0.39% |
| Tracking Difference | -1.05% | - |
Historical performance and flows
As of October 22, 2026
| 1M | 3M | YTD | 1Y | 3Y | ||
|---|---|---|---|---|---|---|
| Perf. | XDNA | -1.40% | +26.06% | +60.72% | +68.31% | +141.60% |
TDOC.U | +5.90% | +12.84% | +9.97% | +13.42% | +36.78% | |
| Flows | XDNA | +$3 M | +$7 M | +$9 M | +$9 M | +$9 M |
TDOC.U | +$0 M | +$0 M | -$0 M | +$0 M | +$1 M |
XDNA vs TDOC.U exposure
Countries
XDNA
USA
63.68%
Germany
7.53%
Other
28.79%
TDOC.U
USA
61.11%
Switzerland
7.91%
Japan
7.48%
Other
23.51%
Sectors
XDNA
Healthcare
99.80%
TDOC.U
Healthcare
99.36%
As of October 22, 2026
Top 10 Holdings
XDNA
Moderna, Inc.
8.85%
Twist Bioscience Corp.
6.01%
Revolution Medicines, Inc.
4.12%
Bayer AG
4.08%
Genmab A/S
4.00%
Regeneron Pharmaceuticals, Inc.
3.76%
Merck & Co., Inc.
3.66%
Vertex Pharmaceuticals, Inc.
3.65%
Incyte Corp.
3.60%
Takeda Pharmaceutical Co., Ltd.
3.49%
TDOC.U
Thermo Fisher Scientific, Inc.
2.29%
Pfizer Inc.
2.24%
Merck & Co., Inc.
2.22%
Amgen, Inc.
2.21%
Bristol Myers Squibb Co.
2.20%
Abbott Laboratories
2.19%
Danaher Corp.
2.12%
Medtronic Plc
2.09%
Vertex Pharmaceuticals, Inc.
2.07%
McKesson Corp.
2.05%
Diversification
XDNA
Total weight of top 10 holdings out of 47 total
45.23%
TDOC.U
Total weight of top 10 holdings out of 108 total
21.67%
Characteristics
Compare
XDNA
TDOC.U
| Provider | iShares | TD Asset Management |
| Management | Passively managed | Passively managed |
| Benchmark | NYSE FactSet Global Genomics and Immuno Biopharma NR Index - CAD | Solactive Global Healthcare Leaders Index (CA NTR) - CAD |
| Replication Method | Direct (Physical) | Direct (Physical) |
| Asset Class | Equity | Equity |
| Dividend Policy | Distributing | Distributing |
| Trailing 12m distribution yield | 0.20% | 1.16% |
| Meets ESG criteria | No | No |
| Inception Date | April 26, 2022 | February 24, 2022 |
Frequently asked questions about XDNA and TDOC.U
Which ETF has performed better year to date: XDNA or TDOC.U?
As of October 22, 2026, XDNA has returned 60.72% year to date, while TDOC.U has returned 9.97%. XDNA is ahead on YTD performance.
Which ETF is larger by assets under management: XDNA or TDOC.U?
As of October 22, 2026, XDNA manages $19.37 M in assets, while TDOC.U manages $3.32 M. XDNA is the larger fund by AUM.
How are XDNA and TDOC.U managed?
XDNA is passively managed by iShares. It tracks the NYSE FactSet Global Genomics and Immuno Biopharma NR Index - CAD benchmark. TDOC.U is passively managed by TD Asset Management. It tracks the Solactive Global Healthcare Leaders Index (CA NTR) - CAD benchmark.
What sectors do XDNA and TDOC.U emphasize?
XDNA is most exposed to Healthcare. TDOC.U is most exposed to Healthcare.
Which ETF is attracting more investor flows: XDNA or TDOC.U?
Year to date, XDNA has seen +$9.50 M in net flows, compared with -$0.02 M for TDOC.U. XDNA has attracted more net investor money so far.
How do the fees of XDNA and TDOC.U compare?
XDNA has an expense ratio of 0.44%, while TDOC.U has an expense ratio of 0.39%.
What are the top holdings of XDNA and TDOC.U?
XDNA's largest holdings include Moderna, Inc., Twist Bioscience Corp., and Revolution Medicines, Inc.. TDOC.U's top holdings include Thermo Fisher Scientific, Inc., Pfizer Inc., and Merck & Co., Inc..
Which ETF is more diversified: XDNA or TDOC.U?
XDNA holds 47 securities, while TDOC.U holds 108. On holdings count, TDOC.U is the more diversified portfolio.
Recent articles about XDNA and TDOC.U
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